Friday, August 31, 2018

organic chemistry - Order of halide nucleophilicity in DMF


The order of nucleophilicity for halide family in DMF is: ClX>BrX>IX. I understand the reason for this must be that DMF, being a polar aprotic solvent, is unable to solvate the halide ions.


I was told by my teacher that this is true only for DMF and DMSO, while in other aprotic polar solvents, the order is as usual: FX<ClX<BrX<IX.


I'd like to know what is special about DMF and DMSO (and which is not possessed by other aprotic solvents like acetone) that leads to this order.


I have verified the order in DMF from March's 7th edition (page 427). The book mentions the usual order (ClX<BrX<IX) for acetone (another aprotic polar solvent).




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